Why COP vial not glass bottle

In recent years, my country's modern biotechnology represented by genetic engineering, cell engineering, and enzyme engineering has developed rapidly, and the complexity and sensitivity of biopharmaceuticals have also changed. As a result, glass, a conventional bottle-making material, cannot fully meet the high-end requirements. In this context, packaging materials suitable for high-end drugs such as COP bottles have ushered in development opportunities.

5ml COP vial

100ML COP bottle

DMF check

Glass materials have protein adsorption properties, and the adherence of drugs to the glass surface will reduce the utilization rate of drugs in the packaging, which means that pharmaceutical companies need to overfill the drugs to compensate for product losses, which will adversely affect production efficiency and manufacturing costs. To solve the problem of protein adsorption, the adsorption can be reduced by adding a high concentration of inert protein to the drug formula or treating the glass surface with silicone oil. Therefore, it is an ideal solution to solve the problem of protein adsorption by changing the way of packaging materials.

At present, a high-quality packaging with low protein adsorption, low refractive index, and no delamination in drug compatibility tests has been widely used abroad, that is, cyclic olefin polymer (COP). Compared with glass materials, this material has higher transparency and can be used for drugs with pH greater than 9, lymphocyte antigens such as Avastin, Alemtuzumab, Opdivo, Primavera, Etanercept, etc. Drugs such as anti-tumor drugs and anti-tumor drugs are packaged in COP bottles.

Although the price is higher than that of glass materials, the COP bottle can effectively reduce the adsorption of drugs on the surface of the container and improve the utilization rate of drugs, thereby saving the cost of very expensive overflow of biological drugs. From this point of view, it should be enough to offset the higher cost of COP plastic bottle cost.