An effervescent tablet is a special tablet containing an effervescent disintegrant. This medicine is easily decomposed by moisture. Therefore, a desiccant is placed inside the effervescent tube to absorb the moisture inside the packaging and the tablet itself to ensure the tablet’s moisture content stability.
At present, the desiccants used for pharmaceutical packaging on the market are mainly silica gel and molecular sieves, while the desiccant inside the effervescent tube is a mixture of silica gel and molecular sieves in equal proportions. These two desiccants have their own advantages:
Silica gel desiccant: Silica gel is a commonly used desiccant, in the form of translucent granules. Because this substance has a porous structure and has a large adsorption area, it can adsorb many substances. The color in silica gel is added with cobalt chloride to indicate efficacy. Cobalt chloride is blue when there is no water, and becomes pink after absorbing water. Silica gel cannot be absorbed in the gastrointestinal tract and can be excreted through feces. It is not toxic to the human body. Therefore, it is not necessary after taking this desiccant by mistake Special treatment, but cobalt chloride is toxic, so the blue discoloration silica gel desiccant is toxic.
Molecular sieve: Molecular sieve is a synthetic desiccant product that has strong adsorption to water molecules. Its structure is like a sponge, with densely packed pores arranged in it, and the pores are interconnected and criss-crossed. According to calculations, the inner surface area of the holes in the molecular sieve per gram can reach more than 800 square meters. When different substances pass through the molecular sieve, only some small molecules can flow unimpeded, and other molecules either linger outside or are adsorbed in the pores. , Can not break free, so as to achieve the purpose of screening molecules. This is also the origin of the name "molecular sieve".
Relatively speaking, silica gel desiccant can effectively control the number of water molecules for a long time, while molecular sieve can quickly absorb water molecules. After the two desiccants are mixed in equal proportions, they can achieve a good drying effect and ensure the dryness of the effervescent tube.
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