Several sterilization methods for COP bottles

Medicines are basic items used to prevent, treat, and diagnose diseases. Sterility is the basic requirement of medicines. For COP bottles used for lymphocyte antigens, hormone drugs, narcotic drugs, and drugs with a PH value of greater than 9. Said is no exception.

After the COP bottle is produced, it can be put into use after being sterilized. The commonly used sterilization methods include the following:

Ethylene oxide sterilization: Ethylene oxide (EO C2H4O) is a commonly used gas sterilizing agent, which destroys and eliminates the activity of proteins by chemically reacting with macromolecules in the cell, so that the microorganisms are killed and sterilized purpose. Usually used for heat-sensitive and moisture-sensitive materials.

COP vial

Gamma-ray sterilization: Gamma-ray sterilization is that after gamma-ray irradiation, the chemical substance (DNA) in the microorganisms has changed, causing the loss of cell viability, so as to achieve the purpose of sterilization. The general plastic material will turn yellow after gamma-ray sterilization, while the COP bottle has a good low birefringence and is not easy to change color after irradiation.

Steam sterilization: Steam sterilization is to put the items to be sterilized in a closed pressure sterilization pot. By heating, the water in the compartment of the sterilization pot is boiled to generate steam. When the water vapor sharply puts the pot into the pot The cold air is driven out from the exhaust valve, and then the exhaust valve is closed and heating is continued. At this time, the pressure in the sterilizer is increased because the steam cannot overflow, thereby increasing the boiling point and obtaining a temperature higher than 100°C. It leads to coagulation and denaturation of bacterial protein to achieve the purpose of sterilization.

Electron beam sterilization: Electron beam sterilization is the electron beam produced by the 10MEV high-energy electron accelerator. This electron beam beam acts on the DNA on the surface and inside of the product, effectively destroying or killing the DNA on the surface of the product, and effectively killing the product The various microorganisms inside have strong penetrating ability and thorough sterilization ability. For example, the bacteria, molds and coliforms that people encounter every day can not be detected after being processed by electron beams. Medical companies require very Strict medical sterility is achieved through this technology.

The above are several commonly used sterilization methods for COP bottles. In addition, in the packaging production process, attention should be paid to the control of factors such as raw materials and production environment to ensure that the pharmaceutical packaging is produced in an environment that meets the requirements of national standards.