The potion is invalid? 99% is related to this indicator of the eye drop bottle

With the promotion and popularization of the application of electronic products, there are more and more ocular diseases caused by overuse of the eyes, thus creating an increasingly large ophthalmic medicine market. Among various types of ophthalmic medicines, the most common form of medicine is liquid eye drops, which are basically pharmaceutical packaging in plastic eye dropper bottles that are easy to squeeze.

10ml eye dropper vial with LDPE

The sealing performance of the eye drop bottle is related to the stability of the drug effect during the shelf life of the drug. This is because for liquid eye drops, if the packaging is poorly sealed, the liquid inside the package is likely to leak, which is intuitive The performance of the package is leaking. In addition, the poor sealing of the package will also cause the eye drops to contact more air, causing some components in the liquid medicine to oxidize, lose the efficacy, and even cause many harm to the eyes, affecting the eye drops within the shelf life Product quality. Therefore, the sealing performance of the eye drop bottle cannot be ignored.

Generally, the tightness of eye drop bottles is tested by the following methods:

(1) Take several test bottles. Under the condition of a torque of 55~80N·cm, the mouth and the cap should match properly without slipping teeth.

(2) Take several test bottles, open the bottles first, then tighten the caps (use a force measuring wrench to tighten the caps of the test bottles, the torque is 55~80N·cm), and place them in a container with a suction device Afterwards, add a baffle, immerse in water, vacuum to a vacuum of 20kPa, and maintain for 2 minutes. There should be no water or bubbling in the bottle.

Eye drops are in direct contact with the eyes. The good tightness of the eye drops bottle has an important impact on preventing the liquid from leaking during storage and maintaining good efficacy. Pharmaceutical companies should pay more attention to packaging safety when choosing packaging. Efforts to ensure drug safety.