How to detect the easy oxide content of child proof bottle bottles

Plastics have a broad market in the pharmaceutical packaging industry, and the performance requirements of pharmaceutical packaging are generally relatively high, especially in terms of thermal stability, airtightness, drug compatibility, and other aspects. There are relevant national and industry standards. To obtain passes in related fields, the standards must be met. Claim. HDPE bottles are a common type of packaging used in the pharmaceutical packaging industry. To ensure the safety of drugs, pharmaceutical packaging materials will be tested for easy oxide content. Then, how to detect the easy oxide content of high-density polyethylene bottles What?Easily oxides refer to substances that are prone to chemical reactions with oxygen in ordinary environments, such as iron, copper, aluminum, etc. The most common are metals that are prone to rust. However, in the pharmaceutical packaging industry, it generally refers to many substances that are prone to oxidation with oxygen, such as organic matter, reducing agents, sulfur, and phosphorus, which are all easy oxides. The easy oxide content of packaging materials is the main national technical standard.

High-density polyethylene bottle easy oxide detection method: accurately measure 20mL of water as the test solution, accurately add 20mL of potassium permanganate titrant (0.002mol/L) and 1mL of dilute sulfuric acid, boil for 3 minutes, quickly cool, add 0.1g of potassium iodide , Placed in a dark place for 5 minutes, titrate with sodium thiosulfate titrant (0.01mol/L), when the titration is near the end point, add 5 drops of starch indicator solution, continue titration until it is colorless, take another water blank solution and operate in the same way. The difference in consumption of sodium thiosulfate titrant shall not exceed 1.5 mL.

Child proof bottles are widely used in pharmaceutical packaging, and their easy oxide content will have a negative impact on the safety of drugs. Pharmaceutical companies should pay attention to whether their packaging meets the standards when choosing pharmaceutical packaging materials suppliers, laying a foundation for drug safety and stability. Good base.