Molnupiravir is an antiviral drug that inhibits the replication of certain RNA viruses. For the treatment of COVID-19 in people infected with SARS-CoV-2. It belongs to a small molecule drug and is in the form of capsules. What are the requirements of this drug for moisture-proof packaging of drugs?
Capsules refer to capsules made of special film-forming materials (such as gelatin, cellulose, polysaccharides, etc.), into which the contents (such as powdered and liquid medicines, etc.) or doses are loaded for easy swallowing. Medicines in capsules are generally powders or granules that are irritating to the esophagus and gastric mucosa, or have bad taste, are easily volatile, are easily decomposed by saliva in the oral cavity, and are easily inhaled into the trachea. These medicines are packed into capsules, which not only protect the medicinal properties of the medicines from being destroyed, but also protect the digestive organs and respiratory tract. Removing the capsule shell may result in drug loss, drug waste, and reduced efficacy. In addition, some drugs need to be dissolved and absorbed in the intestine, and the capsule protects the drug from being destroyed by stomach acid.
Molnupiravir's requirements for moisture-proof packaging of pharmaceuticals are mainly moisture-proof and airtight. These drugs are very sensitive to water molecules, and are prone to adhesion and deliquescence after being exposed to moisture, and their efficacy is greatly reduced, and sometimes there are toxic and side effects. In order to maintain the stability of the internal environment of the packaging, a desiccant will be included in the moisture-proof packaging of medicines to absorb moisture. There are also strict requirements for indicators such as the water absorption rate of the desiccant. In terms of sealing, it is mainly the ability of the bottle mouth and the bottle cap to cooperate, and to ensure the accuracy of the size, in order to better ensure the good sealing of the package.
The above are the two requirements of Molnupiravir for moisture-proof packaging of drugs, which are also two very important aspects to maintain drug stability and safety. Pharmaceutical companies should pay attention when choosing packaging.
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