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Protecting the stability of drug efficacy: moisture-proof design of effervescent tube

Jul 25 , 2024

In modern pharmaceutical packaging, moisture resistance is one of the most important considerations, especially for special packaging forms such as effervescent tubes for oral solid drugs. The moisture resistance of effervescent tubes depends not only on the design of the internal desiccant, but also on the strict requirements of the packaging material - white paper.

Effervescent tubes with spiral caps information

Effervescent tube

The desiccant inside the effervescent tube cap is mainly composed of a mixture of silica gel and molecular sieves. This design ensures long-term and effective control of the number of water molecules. Silica gel can continuously and stably absorb moisture, while molecular sieves quickly absorb moisture in a short time. Together, they ensure that the stability and effectiveness of the drug are not affected by the humid environment.

The key is that the desiccant is sealed by white paper, which must meet strict national standards, such as moisture content less than 6%, no arsenic more than 0.0001% and no lead more than 0.0005%. These requirements ensure the high quality and stability of white paper, and avoid the barrier effect of excessively thick paperboard or excessive moisture content affecting the performance of the desiccant.

The manufacturing and quality standards of the effervescent tube follow the national standard YBB00172004-2015 "Oral Solid Medicinal Low-density Polyethylene Moisture-proof Combined Bottle Cap", in which the specifications of the white paper are strictly controlled at 0.46-0.55mm pure high-quality wood pulp white cardboard to ensure that the drug contact surface has no flake fluorescence after inspection under ultraviolet light.

Requirements for the moisture content of the desiccant in the effervescent tube

caps for effervescent tube

The effervescent tube performs well in protecting the stability of drug efficacy. The key to its moisture-proof performance lies in the high-quality white paper material and precise desiccant design. This high-standard manufacturing process not only ensures the safety of drugs during storage and transportation, but also sets a good example for the development of modern pharmaceutical packaging technology.


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