Cell-based drugs usually contain living cells and have high added value, so the storage conditions are very strict. Storage in liquid nitrogen is the key to ensuring the activity and stability of cell-based drugs, because the ultra-low temperature of liquid nitrogen (-196℃) can effectively inhibit cell metabolism and maintain the therapeutic effect of the drug. However, to ensure the activity and stability of the drug, it is crucial to choose the right packaging material.
The packaging of cell-based drugs needs to meet the following key requirements:
Low protein adsorption
Cell-based drugs usually contain active protein components, such as cytokines or growth factors, so the packaging material must have low protein adsorption. This can effectively reduce the loss of protein and prevent the drug components from being adsorbed on the packaging surface, thereby ensuring the dosage and efficacy of the drug.
Low temperature resistance
Since cell-based drugs are usually stored for a long time in liquid nitrogen (-196℃), the packaging material must have excellent low temperature tolerance. This is the premise for ensuring that the stability and activity of the drug are maintained during storage.
Chemical stability
The packaging material must have sufficient chemical stability to withstand high-intensity treatments such as irradiation sterilization without deterioration or release of harmful substances, ensuring the safety of the drug.
COP vials - ideal packaging choice
For these stringent requirements of cell-based drugs, COP (cycloolefin polymer vials) provides an ideal solution. It uses high-performance cycloolefin polymer materials and has the following significant advantages:
1. Low temperature tolerance: It can withstand an extremely low temperature environment of -196°C, ensuring that cell-based drugs are stable and worry-free during liquid nitrogen storage. This feature makes it an ideal choice for the storage of cell-based drugs and other high-end biological preparations.
2. Low protein adsorption: It has very low protein adsorption, which effectively avoids the contact between the protein components in cell-based drugs and the inner wall of the bottle, ensuring that the activity and efficacy of the drug are not lost.
3. Excellent chemical stability: It has excellent chemical stability and will not deteriorate during treatment such as irradiation sterilization, ensuring the safety of the drug and the stability of the packaging material.
4. Reliable sealing and pressure resistance
It still maintains excellent sealing and pressure resistance in low temperature environments, which can effectively prevent the external environment from polluting and damaging the drug, and is an ideal packaging solution for the storage of high-end biological preparations.
In general, the liquid nitrogen storage requirements for cell-based drugs are strict, and choosing the right packaging material is crucial. COP vials have become the preferred packaging material for storing cell-based drugs in the biopharmaceutical industry due to their excellent low-temperature tolerance, low protein adsorption and chemical stability. Whether it is long-term storage or short-term transportation, it can provide all-round protection for your drugs to ensure the quality and safety of the drugs.
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