Cell and gene therapy represents a revolutionary breakthrough in the pharmaceutical industry, but these drugs often rely on ultra-low temperature storage to maintain cell viability and drug stability. Conventional glass vials are prone to seal failure due to uneven shrinkage at -150°C or even liquid nitrogen temperatures (-196°C), increasing the risk of contamination. In contrast, COP vials, with their heat shrinkage properties almost synchronized with the rubber stopper, can maintain seal integrity at extreme low temperatures, making them the preferred packaging for cell cryopreservation formulations.
Polymer Vial 2ml 5ml 10ml for cell and gene therapies
Why do cell therapy drugs need COP vials?
Live cell formulations are extremely sensitive to their environment. Even small temperature fluctuations or seal issues during the cryopreservation process can lead to cell death or loss of function. The unique advantages of COP vials include:
Ultra-low temperature tolerance: They remain stable at -196°C, preventing seal failure caused by material shrinkage differences and ensuring the long-term safety of cell formulation storage.
Leak-proof design: COP vials are less likely to break during repeated freeze-thaw cycles, reducing risks during transportation and storage, particularly suited for therapies like CAR-T and stem cells, which require multiple transfers.
Biocompatibility: COP vials contain no leachables, avoiding interference with cell viability or gene carriers (such as viruses or mRNA), and meeting the strict packaging standards set by the FDA and EMA for cell therapy.
Reduced protein adsorption, precise dose control: In addition to cell therapy, COP vials are also suitable for gene-editing drugs (such as CRISPR vectors) and recombinant protein drugs. These high-value biologic drugs can easily adsorb to the surface of glass, leading to dosing inaccuracies. The low protein adsorption properties of COP material reduce drug loss, ensuring clinical dosing accuracy and helping pharmaceutical companies optimize their filling processes and reduce cost waste.
Future Trend: COP Vials Will Become the Standard Packaging for Cell and Gene Drugs
With their deep-freeze tolerance, high sealing properties, and biological safety, COP vials are being used by leading global pharmaceutical companies for cutting-edge fields like mRNA vaccines and CAR-T cell therapies. For companies dedicated to the development of cell and gene therapies, choosing COP packaging is not only a compliance requirement but also a crucial step to ensuring the effectiveness of the drugs.
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