What are the characteristics of rubber stopper of COP vial

COP vial is a transparent plastic bottle made of cycloolefin polymer. It is mainly used to contain anti-cancer drugs, PH value greater than 9 and accurate dosage requirements. These drugs are generally injectable preparations, and the lid of the package will have a rubber stopper to ensure a better seal.

5ml COP vial

100ml COP injection vial

The rubber stopper used for COP vials is generally a butyl rubber stopper, which is a copolymer of isobutylene and a small amount of isoprene or butadiene. It is characterized by good air tightness, good ozone resistance, good aging resistance, high heat resistance, long-term working temperature can be below 130 ℃; resistance to strong inorganic acids (such as sulfuric acid, nitric acid, etc.) and general organic solvents, good vibration absorption and damping characteristics , Electrical insulation is also very good.

Although it has good performance, due to the complexity of the formula and the concentration gradient of the added raw materials, after packaging with some drugs with relatively strong molecular activity, they are absorbed, adsorbed, leached, and penetrated by the drug, resulting in the compatibility of the rubber stopper and the drug The most prominent problems are some cephalosporins, some large infusions, and more traditional Chinese medicine injection preparations. Therefore, by selecting an inert soft coating to cover the surface of the rubber stopper to isolate the direct contact between the drug and the rubber bottle stopper, effectively reducing the absorption, adsorption, leaching and permeation between the rubber stopper and the drug, and improving the long-term stability of the drug; Improve the mechanical lubricity of the rubber stopper; greatly reduce the increase in the number of insoluble particles in the liquid medicine caused by silicone oil.

On the whole, after the butyl rubber stopper is applied to the COP vial, it can greatly improve the overall sealing of the package, thereby ensuring the safety and stability of the drug during storage.