Intranasal Atomization Device-a new painless drug delivery device

The Intranasal Atomization Device is a new drug delivery device consisting of a syringe, a nasal spray device, a push rod and a dose limiter, and is mostly used for vaccines, protein and polypeptide drugs. It converts liquid medicine into mist particles, which can be absorbed through the nasal mucosa to act on specific parts or the whole body. This mode of administration has the following advantages:

Disposable Intranasal Atomization Device

1. Avoid the first-pass effect when the drug is taken orally, and have high bioavailability. Drug metabolism by nasal mucosa is very weak, especially for some drugs that cannot be taken orally administered through the nose.

2. The nasal mucosa has a large area, and the submucosal blood vessels are very rich. The arteries, veins and capillaries are intertwined into a network, and the medicinal liquid can be quickly absorbed and enter the systemic circulation from the blood vessels.

3. Drugs that are easily destroyed in the gastrointestinal tract, drugs that are highly polar and difficult to absorb in the gastrointestinal tract, can be well absorbed by the nasal mucosa, and peptides and protein drugs with large molecular weight can also be absorbed in the presence of absorption enhancers. Absorbs better.

4. The medicine is convenient and easy to be accepted by patients.

5. The absorption rate and degree of nasal administration can sometimes be comparable to that of intravenous injection.

At present, the Intranasal Atomization Device has been applied to a variety of drugs, protein and polypeptide drugs, drugs that are difficult to absorb orally, are very unstable in the gastrointestinal tract, and are obviously affected by the first-pass effect of the gastrointestinal mucosa and liver, as well as vaccines, etc. It is suitable for the types of drugs required for nasal administration, etc.